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Description

MSO and PPT inhibition studies in Pf and Pb In vitro inhibition, studies were carried out either in RPMI-1640 lacking L-glutamine (RPMI -gln ) or RPMI-1640 medium containing physiological concentrations (0.5 mM) of L-glutamine (RPMI Pgln )

APX and GR are the key enzymes of the AsAGSH cycle

Evaluation of Pharmacodynamic Response Improvement due to Increased Drug Delivery The final aim of the transporter-mediated drug delivery approach is to increase the concentration of the delivered drug at the target site in the brain, resulting in higher pharmacological response