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This further confirms that Vitamin D 3 should serve as adjunctive therapy rather than primary treatment, mainly correcting deficiency

Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]

Bone Mineralisation: Studies examining the effect of pulsatile GH release on osteoblast function and bone density in animal models

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