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Discussion Despite several studies into the biology and genetics of hair greying or canities, the mechanism by which human scalp hairs lose pigmentation remains poorly understood, due in part to the complexity of interaction between different cell types, complex protein interactions, differential gene expression during the hair growth cycle, and variable conditions that occur within the hair follicle microenvironment 1,7,8,9,10,13,41,60,69,70,71,72,73,74

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48,49 In an open uncontrolled trial, a combination of vitex plus soy isoflavones and magnolia ( Magnolia officinalis ) for 12 months reduced hot flashes and mood and sleep symptoms in 71 healthy postmenopausal women