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FIGURE 1 Increasing evidence suggests that microbiota, specifically gut microbiota contributes to the drug metabolism ( In this review, we explore the diverse factors contributing to the variability in metformin response among T2D individuals, with a particular focus on recent advancements in genomics, metabolomics, and microbiomics

The soluble factors are important in engaging monocytes, macrophages, and neutrophils in the phagocytosis [34], during which the foreign agents are destroyed by lysosomal enzymes, acidic pH, and radical attacks

Step 6: Maintain consistency