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SLC1A5 , GLS2 and GOT1 are required for glutamine uptake and metabolism to Glu and, ultimately, -ketoglutarate [10]

doi: 10.1093/JXB/ERT423 146 PrasadR.BhattacharyyaA.NguyenQ

Proteomic analysis further demonstrated that hexokinase 2 (HK2), which catalyzes the first step of glycolysis by converting glucose to glucose-6-phosphate, was significantly downregulated at the protein level (Supplementary Fig

Notably, elevated levels of pro-inflammatory cytokines, such as interleukin-1beta(IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and interferon-gamma (IFN-), have been consistently observed in patients with ME/CFS [33, 34]