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In laboratory research, administering 5-Amino-1MQ competitively inhibits NNMT activity, halting the clearance of nicotinamide

We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]