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GPx activity and treatment response Prepost change in GPx activity was negatively associated with prepost change in LSAS-SR, indicating that patients with increased GPx activity showed greater reduction of social anxiety (Adj- R 2 = 0.05, = 0.28, B = 0.26, BSE = 0.11, Z = 2.34, p = 0.024

These findings suggest that excessive use of sulindac may lead to early neurodevelopmental toxicity and increase the risk of hyperactivity, which could be associated with damage to GABAergic neurons

Can J Chem 61:10821085 Brandes N, Schmitt S, Jakob U (2009) Thiol-based redox switches in eukaryotic proteins

While Levodopa remains the gold standard, its limitations necessitate combination therapy and adjunct modalities such as deep brain stimulation and nanocarrier-based drug delivery