is glutathione a phase 1 or phase 2 conjugator II Reactions: Conjugation and Mercapturic Acid Formation | Definition, Examples & FAQs Hepatotoxicity pathophysiology - wikidoc

1.2.3 P62-Keap1-Nrf2 signal transduction pathway Other molecular signal pathways related to ferroptosis, including p62-Keap1-Nrf2 signal transduction pathway, bind to Kelch-like ECH-related protein 1(Keap1) under oxidative stress, and remain inactive through ubiquitination in proteasome, and then release Nrf2 from the coupled Keap1 protein and transfer to the nucleus (45)

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