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These effects were generally mild to moderate in intensity and were most frequent during the dose escalation period, becoming less common as participants remained on their maintenance dose

doi: 10.1097/00004836-198606000-00016

3.5.2 Activation of the Keap1Nrf2 pathway and detoxification ITCs are potent activators of the Keap1Nrf2 signaling pathway, which upregulates cytoprotective genes