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Chapter 22: Autoimmune diseases, Pernicious Anemia (Vitamin B12 Deficiency) PERNICIOUS ANAEMIA (PA) Definition This is megaloblastic anemia due to deficiency of vitamin B12, because of malabsorption, which is believed as an autoimmune phenomenon to gastric parietal cells and their products

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For instance, prominently stimulated expression of the egr-1 gene includes cytokine and growth factor generation, and early extracellular matrix (collagen) formation, and blood vessel function and its repressor naB2 (55), very likely provides a particular feedback-process consistently responsible for the simultaneous healing of two different tissues and fistulas healing (10-12)