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SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

Blood 114(22):805, 2009

The benefit of such approach is that the normal body cells are not considerably affected since they harbor basal levels of ROS and are less reliant on antioxidants

In the acute phase of ischemia, which is characterized by anoxic depolarization and a massive increase in [Ca 2+ ] i mediated by both Ca 2+ influx and Ca 2+ -induced Ca 2+ release from intracellular stores, the vesicular release from presynaptic terminals further adds to the glutamate elevation