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[PubMed Citation] INTRODUCTION: This article reports the results of a retrospective study of 8 years of experience of the Paris Fire Brigade with the prehospital use of hydroxocobalamin

In randomized clinical trials of VTE prophylaxis in adults during the peri-operative period following hip fracture, hip or knee replacement surgery, and abdominal surgery, major bleeding occurred at a higher rate among adults with a body weight less than 50 kg compared to those with a body weight greater than 50 kg (5.4% versus 2.1% in adults undergoing hip fracture, hip replacement, or knee replacement surgery

The ideal frequency varies based on your individual needs