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As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease

21,24 Pediatric Considerations Pain control is especially important for pediatric patients since unmanaged pain can develop into hyperalgesia (excessive response to pain)

Future research should integrate multi-omics, neuroimaging and artificial intelligence-driven subtyping to develop personalized, mitochondria-targeted interventions

1, E to G)