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Specifically, the drug resistance mechanisms of HGSOC are primarily manifested in tumor cell heterogeneity, which leads to significant differences in drug response among various cell subpopulations

Data suggests a short half-life and bioavailability of about 30% due to certain mechanisms, including hepatic degradation, reduced solubility as well as instability in the stomach [91]

256 However, in various clinical trials investigating its antitumor efficacy, siltuximab monotherapy demonstrated limited clinical activity, prompting a strategic shift toward exploring its role in combination therapies