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Outside the CNS, serotonin is produced in the ENS and released predominantly by enterochromaffin cells (estimated to be up to 90% of the body's serotonin production [169]) of the gut mucosa and immune cells, with influence not only on the ENS but also on the CNS via the GBA [283]

Its supported by multiple lines of evidence, and illustrates precisely why the gut-immune axis matters in the real world

Gubert C, Stertz L, Pfaffenseller B et al (2013) Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects

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