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72,73,74 Although it is well known that HIF-1 decreases ROS production, Chen et al

Its expression is significantly increased in lung adenocarcinoma, downregulated in gastric and colorectal cancers and altered during the differentiation of pluripotent embryonic stem cells ( CHAC2 was upregulated in a model of APAP-induced hepatic damage following treatment with naringin ( 3.1 CHAC2 and cancer In contrast to CHAC1, the general role of CHAC2 in cancer and programmed cell death remains elusive