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For the concern that some hospitals may inappropriately use observation status to circumvent the measure's intent, we note that clinicians are responsible for adhering to all standards for patient care, including using appropriate clinical decision making to determine which patients should be placed in observation status

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Additional follow up studies could include lysine supplements, as it was found that multiple participants were not consuming a minimum daily requirement in their diet

Treatment strategies remain limited, focusing on symptomatic management, neuroprotective interventions, and behavioral therapies