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Front Psychiatry 9 , 767 (2018)

In addition, taurine has high specificity and affinity for glycine receptors (Albrecht and Schousboe, 2005) and by binding to these receptors mediates glia-neuron signaling in the hypothalamus and excitatory neurotransmission in early development of the neocortex and brain stem (El Idrissi and Trenkner, 2004

Compared to APOE3 and APOE2, APOE4-mediated pathways of A clearance are impaired, and APOE4 exhibits a higher affinity interaction with A, potentially driving a more severe A plaque burden, 119,121,123 making it one of the strongest genetic risk factors for AD