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In such conditions, insufficient peroxisomal fatty acid processing could increase mitochondrial substrate pressure, whereas persistent mitochondrial dysfunction would in turn impair completion of oxidative disposal, establishing a self-reinforcing loop of NEFA accumulation, ROS production, and necroinflammation (60, 61)

Future research into their efficacy and safety will further illuminate their role in skincare and broader health management strategies

This is the case that in our current study, we clearly detected a significant increase of Fe 2+ signal (Figure 1), and noticeable changes in the balance of GPx4 and FACL4 following CSD (Figure 2)

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