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It would require multigenerational monitoring, necessitating registries that document clinical outcomes and epigenetic markers across a minimum of two descendant cohorts

For Healthcare Professionals Vitamin B12, part of the vitamin B-complex family, refers to the group of compounds that consists of cyanocobalamin, hydroxycobalamin, and related substances (1)

The molecular composition of MPT operating at both MOM and MIM are not well-understood at present, despite evidence indicating a role for voltage-dependent anion channel (VDAD) and adenine nucleotide translocase (ANT) in the regulation of MPT

The proposed mechanism for hyperhomocysteinaemia on inducing endothelial dysfunction and thus atherosclerosis includes homocysteine-induced endoplasmic reticulum stress, oxidative stress, and proinflammatory response.48 Animal models of hyperhomocysteinaemia have confirmed the causal relationship between hyperhomocysteinaemia and the development of endothelial dysfunction and accelerated atherosclerosis.48 Although meta-analyses have shown reduction of cardiovascular risk with reduction of homocysteine levels,46 47 vitamin supplementation (with vitamin B 6 , vitamin B 12 , and folic acid) to lower homocysteine in the body may not be transformed into clinically beneficial vascular outcomes