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However, when the limit for storage of TAGs is reached or adipocyte lipolysis is dysregulated, FAs can accumulate in ectopic tissues such as skeletal muscle and the liver leading to insulin insensitivity and T2D (11)

On the other hand, MetS-induced OS may be related to impaired antioxidative activity (130)

[1] , [2] , [3] , [4] , [5] Glutathione, Placenta, Vitamin C, Vitamin B2, Vitamin E, A

Although the generation of malfunctioning mitochondria may be counterbalanced by elevated levels of mitophagy, a form of macroautophagy that is able to degrade mitochondria, it is not yet clear in the literature how mitophagic activity is generally changed in affected cells of PD patients ( Figure 7 The role of mitochondrial dysfunction and increased oxidative burden in neural aging was also investigated in dogs