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Electron leakage occurs when NAD and FAD become overly reduced or when quinone is partially reduced to semiquinone, increasing the likelihood of superoxide or hydrogen peroxide formation within mitochondria

This system is necessary because long-chain fatty acyl-CoA species do not freely cross the inner mitochondrial membrane as CoA thioesters

doi: 10.1016/S0140-6736(17)32448-0 23 KuenzigMEFungSGMarderfeldLMakJWYKaplanGGNgSCet al

1,2 While rarely used, the monoamine oxidase inhibitor (MAOI) selegiline may also cause false-positive amphetamine results due to its l-amphetamine and l-methamphetamine metabolites