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According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, MUD includes symptoms of craving, an inability to curtail use despite negative consequences, continuing to use methamphetamine at the expense of other activities, the development of tolerance and experiencing a withdrawal syndrome on abrupt cessation of use [3]

Oxidative stress has been also associated with altered calcium (Ca 2+ ) homeostasis in FRDA (Yang et al., 1999

Shenqi Fuzheng injection modulates tumor fatty acid metabolism to downregulate MDSCs infiltration, enhancing PD-L1 antibody inhibition of intracranial growth in Melanoma

Knockout of LAMP-2 hindered autophagosome-lysosome complex formation, resulting in the buildup of autophagosomes, limited zymogen granule degradation, and abnormal trypsinogen activation, exacerbating AP (107, 108)