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While these pancreatic multi-omics resources offer unprecedented resolution of intra-organ heterogeneity, they remain focused almost exclusively on the pancreas and currently do not include matched profiles of the gut microbiome, despite the growing recognition of the gutpancreas axis in metabolic disease

Products of natural origin must thus be taken into consideration along with current conventional therapies in regenerative medicine [81] as well as novel cell therapies, such as promising mesenchymal cell therapy [82, 83]

Another independent study uncovered a novel ANG signal peptide mutation, and careful analysis revealed an allelic association with the rs11701 nucleotide polymorphism (SNP) in familial ALS (FALS) (Conforti et al

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