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Ginseng could act by reducing the NF-B pathway, which in turn decreases the production of proinflammatory cytokines such as TNF-, IL-6, and IL-1, which could be inhibiting ACTH and cortisol secretion (4346, 252, 253)

Vinpocetine Vinpocetine (which may also be labeled as periwinkle extract) may cause adverse effects in pregnant women, reduce fetal weight or increase the risk of miscarriage, and the FDA advises women who are pregnant or could become pregnant not use this supplement (FDA 2019)

In contrast, the placebo groups two out of seven patients carried out similar action