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However, important limitations remain

Plasma lipid-profile measurements showed that the total cholesterol levels were ~30% lower in treated DIO mice relative to control DIO mice ( P 15% relative to NNMT) human methyltransferases (e.g., COMT) or functionally distinct SAM-dependent DNA (e.g., DNMT1) and protein (e.g., PRMT3) methyltransferases with primary and tertiary structures highly similar to NNMT

Research published in Endocrinology demonstrated that both human growth hormone and AOD-9604 significantly increased the expression of beta-3 adrenergic receptors in adipose tissue, restoring suppressed receptor levels in obese animal models to match those in lean controls

Current research priorities include large-scale studies to better understand the tissue-specific effects of NNMT inhibition and the temporal dynamics of metabolic reprogramming following treatment