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Mixing alcohol and amitriptyline increases the risk of excessive sedation, impaired coordination, slowed reaction times, and potentially serious side effects, especially in older adults, those with reduced liver function, and those who have substance abuse disorder

Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, et al

The scavenging effect of curcumin, piperine and their combination against physiological relevant reactive pro-oxidant species using in vitro non-cellular and cellular models