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This is not by itself disqualifying many compounds begin life in a single laboratory but external replication is the standard the literature has not yet met for the VEGFR2/eNOS mechanism or the rodent connective-tissue effect sizes

Sparse clinical evidence versus real-world experience In a review of the evidence posted ahead of the meeting, they repeatedly note the data comes primarily from preclinical work involving animals and is quite limited for humans

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Patients should work closely with their providers to weigh the benefits against any risks and ensure appropriate monitoring