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Preclinical research demonstrated that SS31 protects against mitochondrial dysfunction across multiple disease models including heart failure, ischemiareperfusion injury, neurodegeneration, chronic kidney disease, and agerelated muscle atrophy [9]

Before analysis, cells were washed once with PBS, incubated in 175 l XF base media (Agilent Technologies) supplemented with 2 mM glutamine with or without 100 nM insulin, and incubated at 37C without CO 2 for 1 hour

Mol Aspects Med 30:112 Frade J, Pope S, Schmidt M, Dringen R, Barbosa R, Pocock J, Laranjinha J, Heales S (2008) Glutamate induces release of glutathione from cultured rat astrocytes - a possible neuroprotective mechanism

The disorder can spread throughout the whole body, leading to tumors and unusual skin pigmentation