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Poor communication between the brain and gut could cause changes in brain 5-HT and tryptophan concentrations, leading to anorexia and OD ( In addition to various symptoms caused by SARS-CoV-2 infection, the gastrointestinal symptoms caused by COVID-19 are also closely associated with the imbalance of gut microbiota, which could also influence other systems through various axes (Scheithauer et al., 2024

Clin Chim Acta 90:37 Seiva FRF, Chuffa LGA, Braga CP et al (2012) Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations

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Once in the nucleus, the NF-B dimers p50/RelA and p50/c-Rel then act as transcription factors to activate target genes at the B response element 75