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Our previous work has shown that SLC27A5, inactivated by promoter hypermethylation, is a tumor suppressor gene in HCC [27]

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We then tested whether Hhex expression is directly regulated through AR signaling, so we proceeded to look at HHEX expression following adrenal-specific AR deletion in the adrenal cortex ( ARKO ) by breeding AR flox /Y 60 mice with AS-Cre 55 mice