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Methods: DNA was obtained from participants with BA enrolled in the NIH-supported NIDDK ChiLDReN consortium, a prospective study of cholestatic infants from 14 sites in North America

Since up-regulation of SCN3A has been demonstrated to enhance neuronal excitability and contribute to the development of epilepsy, the reduction of SCN3A expression by VPA due to its promotion on methylation may underlie the anti-epileptic effect of VPA

On the other hand, angiogenesis in the CNS is also essential for processes such as embryonic development, recovery from ischemic stroke-type incidents, and recovery from traumatic brain injury (Vallon and Chang 2014)

Various efforts are made to achieve a positive pregnancy test