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Studies have shown that simple ascorbic acid is the preferred source of vitamin C supplementation

& Wendel, H

B12 is made by bacteria in soil and water and to some extent bacteria in the gut (although production in the gut occurs in a different area to where absorption takes place)

Prostaglandins are chemically unstable PGI2 has a half-life of approximately 3 minutes in aqueous solution at physiological pH, hydrolyzing non-enzymatically to the stable but biologically inactive 6-keto-PGF1