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However, heterozygous adult ABCB4 carriers exhibit a wide range of clinical presentations

This group described decreased activity of nicotinamide N-methyltranserase (NNMT), an enzyme that catalyzes the N-methylation of nicotinamide and other pyridines in the CSF of younger PD patients compared with younger controls, and a trend toward decrease with aging in PD patients (Aoyama et al., The results of studies on neurotoxins related with the risk for PD are based on small series and are not conclusive

Zhao, T., Mu, X

The results revealed the structural changes in loop 3, loop 6 and in the substrate binding site of lysozyme