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Recent drug discovery strategies are based on two criteria: first, compound structures that are distinct from bicalutamide and enzalutamide to avoid cross-resistance and, second, compounds that retain antagonist properties even for known AR mutant proteins that adopt agonist conformations when bound to current AR antagonists (also known as pan-antagonists)

This metabolic alteration has been associated with metabolic diseases or to insulin deficiency 62,63,64

In some patients with COVID-19, damage to organs such as muscles has been reported, resulting in increased CPK and LDH enzymes

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