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doi: 10.1016/J.BBAMCR.2006.05.005 14 BalwaniMDesnickRJ

TCA replenishment involves the use of glutamine or oxaloacetate, which is the product of pyruvate under the catalysis of pyruvate carboxylase (PC) (16)

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In conclusion, collaborative efforts among researchers, clinicians, industry, and regulatory bodies are essential to integrate these platforms into the drug development process