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Bone morphogenetic protein-9 is a circulating vascular quiescence factor

Vangaveti S, Das P, Kumar VL (2021) Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation

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In addition, even although the EPR effect can facilitate the nanotherapeutic distribution to the periphery of tumors via leaky vasculatures 12,13 , efficient intracellular internalization with deep tissue penetration remains unattainable due to the formidable resistance induced by dense extracellular matrix and heightened interstitial fluid pressure on passive diffusion from the perivascular regions to the target cells and/or distal cells, compromising the therapeutic outcome 39