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These pathways were selected because they correspond to the core biological foundations of neurodegenerationproteinopathy, synaptic disfunction, neuroinflammation, mitochondrial impairment, vascular and metabolic dysregulation, among othersthereby anchoring the workflow in mechanisms that are central to dementias and making it applicable across AD, FTD, DLB, vascular and mixed dementias, as well as related neurodegenerative phenotypes that share these pathogenic mechanisms

BauerMPNotermansDWVan BenthemBHBrazierJSWilcoxMHRupnikMet al

Chronic inflammation, often associated with autoimmune diseases, is both a cause and a consequence of leaky gut, creating a cycle of dysfunction.4 Nutritional deficiencies, particularly in zinc, vitamin D, vitamin A, and certain amino acids may also hinder the gut's ability to repair itself

Interestingly, exposure to PQQ leads to increased butyrate levels [137,140], most likely because it is used preferentially as a cofactor for membrane-bound hexose and alcohol dehydrogenases in E