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TGF-1 upregulates HSP47 expression through the MAPK signaling pathway, thereby promoting excessive collagen synthesis ( 2.3 Molecular mechanisms and current research on drug therapy for idiopathic pulmonary fibrosis The global prevalence of IPF has been rising, although some studies suggest a decline in overall mortality, potentially linked to reduced smoking rates, decreased use of immunosuppressants, and new therapies ( Pirfenidone is an orally administered synthetic compound with multiple mechanisms of action

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Molecules 26(16):5001 Kumar A, Yegla B, Foster TC (2018) Redox signaling in neurotransmission and cognition during aging