most abundant glutathione transferase in liver Subnormal Serum Enzyme Levels: A Review of Pathophysiology and Clinical Significance Frontiers | Oxidative stress modulation

The GPx4 isoenzyme (PHGPx) protects against lipid peroxidation by reducing toxic lipid and fatty acid hydroperoxides, including derivatives of cholesterol, providing important neuroprotection (Guloyan 2020) Glutathione is crucial for regulating DNA synthesis and repair, stabilizing cell membranes, protecting cells and proteins from oxidation, modulating cell differentiation, quenching reactive oxygen and nitrogen species, facilitating neurotransmission, and supporting myelin maturation

The findings of the present study about regulation mechanisms of CHAC1 are informative for development of therapeutic strategies through regulation of ferroptosis in IRI

Functions, Types of Peptides and its Role in Research and Medicine

Furthermore, neuronal mitochondria are more vulnerable to oxidative stress and have a slow turnover (Yang et al., 2020)