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Common factors that lead to black circles include: Pigmentation: Under-eye dark circles can be worsened by free radicals and other factors, including radiation, sun exposure, and pollution

In another study, NAC supplementation had no significant effect on serum levels of sex hormone-binding globulin (SHBG), LH, FSH, LH/FSH, E2 and testosterone in PCOS patients after 12 weeks (Reference Ghomian, Khadem and Moeindarbari5,Reference Nasr9,Reference Nemati, Nemati and Taheri12,Reference Badawy, State and Abdelgawad13)