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Description

Inhibiting NADPH oxidases to target vascular and other pathologies: an update on recent experimental and clinical studies

The upregulation of PDI in ALS suggests that a cellular defensive mechanism is triggered against redox dysfunction

Furthermore, rescue experiments with antioxidant N-acetylcysteine (NAC) showed that the expression of 4-HNE and the apoptosis in SGNs were significantly decreased, while the number of surviving SGNs was increased in peroxynitrite + NAC group compared the peroxynitrite-only group and in peroxynitrite + gpx1 / + NAC group vs