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Efficacy in clinical trials, showcasing average weight loss percentages and duration of use

More importantly, the experiments of chemical inhibition and cKS were all carried out in RPMI -gln or RPMI Pgln medium containing ~5 times higher asparagine levels (378 M) than plasma (4080 M), suggesting that the extracellular asparagine could not compensate for the endogenous asparagine deficit in Pf caused by GS inhibition

The research was supported in part by the National Institute of General Medical Sciences (R35GM127045 awarded to S.L.S.), the NCIs Cancer Target Discovery and Development (CTD^2) Network (grant number U01CA217848 and U01CA272612 awarded to S.L.S.), and by the NIBR Scholars Program

However, combinatorial regimens integrating these compounds with conventional chemotherapeutic agents not only potentiate natural product efficacy but also reverse chemoresistance via synergistic ROS-mediated mechanisms