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Moreover, IV therapy can reduce the severity of symptoms by delivering essential nutrients like vitamin C, zinc, and glutathione

The 2DG-induced accelerated decline of cellular ATP in glucose-deprived astrocytes that were exposed to inhibitors of mitochondrial phosphorylation [67] demonstrates that indeed glycolytic metabolism of glycogen-derived glucose phosphate contributes substantially to the glycolytic ATP regeneration in glucose-deprived astrocytes at least during the initial phase of starvation

These observations are consistent with the hypothesis that NFT activates Nrf2, leading to increased GCL synthesis, and subsequently, to a rise in intracellular glutathione levels

Recent data have further highlighted the positional heterogeneity of astrocyte precursors in the spinal cord