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A lack of glucose transporter 1 leads to hypoglycorrhachia and impairment of cerebral energy metabolism, resulting in serious developmental delays, seizures, and complex motor disorders [63]

However, a fine balance is necessary

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Through the regulation of glutamate and GABA, glutamine within the CNS plays an integral role in many aspects of neurobiology and as such disturbances in glutamine metabolism and/or transport have been implicated in a range of pathologies ranging from chronic stress, epilepsy, hepatic encephalopathy, manganese encephalopathy, neurodegenerative disorders and metabolic disease (Reference Huang, Liu and Yin54,Reference Ivens, Caliskan and Papageorgiou55)