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Graphical Abstract Similar content being viewed by others Introduction Alcohol-related liver disease (ALD) has become a major cause of hepatogenic death worldwide, accounting for 47.9% of all liver cirrhosis deaths and 30% of all hepatocellular carcinoma (HCC) deaths [1]

One of the most noticeable changes is that the liver actually shrinks in size , limiting its capacity to handle toxins [15]

Importantly, elevated 4-HNE levels have been reported in -cells from DIO rodents, in islets from db/db diabetic mice, and in islets of T2D human cadaveric donors (158, 165, 174176), suggesting of increased islet PC in T2D

Andersson M, Nieuwerburgh L, Snoeijs P