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In skin research, macro-genomics elucidates the structural and functional characteristics of the skin and gut microbiota, offering valuable insights into microbial alterations associated with skin aging (Figure 2)

Further research confirms that ACSL4 suppression in early ischemic stages is time-dependent and likely driven by increased HIF-1, which binds to the ACSL4 promoter and suppresses its expression (137)

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