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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

5c), indicated significant reductions in key genes of the NF-B and TNF signalling pathways in livers from mice overexpressing AGXT, including Nfkb2 , Relb and Tnf as well as chemokine (CC motif) ligand 2 ( Ccl2 ) and Ccl5 that are known as drivers and therapeutic targets in MASH together with Ccr2 that regulate the recruitment of monocyte-derived cells in MASH 48

The most common drinking-related conditions are overwhelmingly related to the health of our liver

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