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33,34 JNK translocates to mitochondria, binds to SH3 homologyassociated Brutons tyrosine kinase (BTK) binding protein (Sab) on the mitochondrial membrane, and subsequently inactivates a proto-oncogene tyrosine-protein kinase (Src) in mitochondria, eventually leading to the dysfunction of the ETC and the increased release of reactive oxygen species (ROS)

doi: 10.1016/j.biopha.2022.113139

Overall, HFD-mediated lipid accumulation induces lipotoxic stress pathways, ER stress, mitochondrial injury, and apoptosis, impairing granulosa cell viability and oocyte competence

It is primarily distributed in northwestern Chinas inland regions (e.g., Xinjiang, Inner Mongolia, Qinghai) and serves as a dominant species in desert and grassland ecosystems [6]