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Tsai-Turton & Lauderer in their publication in the journal Endocrinology reported that evidence proves oxidative stress (inflammation) induces apoptosis (cell death) in preovulatory follicles and that the antiapoptotic (preventing cell death) effect of FSH is mediated in part by stimulation of follicular glutathione (GSH) and suppression of ROS production

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Nitric oxide also plays a role in iron trafficking because it mimics the consequences of iron starvation and triggers iron uptake by cells

Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation